Jean-Laurent Casanova Selected Research

autosomal recessive Candidiasis familial chronic mucocutaneous

1/2020	Inherited CARD9 Deficiency in a Patient with Both Exophiala spinifera and Aspergillus nomius Severe Infections.
1/2018	Inherited CARD9 Deficiency: Invasive Disease Caused by Ascomycete Fungi in Previously Healthy Children and Adults.
2/2015	Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9.
12/2012	Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis.

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Jean-Laurent Casanova Research Topics

Disease

89	Infections 01/2022 - 02/2002
45	COVID-19 10/2022 - 01/2020
27	Pneumonia (Pneumonitis) 10/2022 - 07/2012
26	Virus Diseases (Viral Diseases) 01/2022 - 03/2003
20	Tuberculosis (Tuberculoses) 01/2021 - 07/2003
18	Chronic Mucocutaneous Candidiasis 11/2021 - 02/2010
15	Chronic Granulomatous Disease 01/2022 - 03/2002
14	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2018 - 10/2002
13	Inflammation (Inflammations) 01/2022 - 11/2005
10	Candidiasis (Moniliasis) 01/2022 - 06/2011
10	Encephalitis (Encephalitis, Rasmussen) 01/2022 - 12/2006
10	Communicable Diseases (Infectious Diseases) 01/2022 - 06/2003
9	Salmonella Infections (Salmonellosis) 08/2021 - 02/2002
8	Bacterial Infections (Bacterial Infection) 01/2019 - 10/2003
8	hypohidrotic Ectodermal dysplasia with immune deficiency 01/2018 - 06/2002
7	Job Syndrome (Hyper-IgE Syndrome) 01/2020 - 09/2012
7	Mycoses (Diseases, Fungus) 01/2020 - 08/2005
6	Autoimmune Diseases (Autoimmune Disease) 03/2022 - 11/2008
6	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2020 - 01/2006
6	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019 - 08/2011
6	Lymphopenia (Lymphocytopenia) 12/2018 - 12/2006
5	Herpes Simplex Encephalitis (Herpes Encephalitis) 01/2016 - 12/2008
4	Neoplasms (Cancer) 01/2022 - 05/2008
4	Human Influenza (Influenza) 01/2022 - 04/2015
4	Critical Illness (Critically Ill) 01/2022 - 01/2021
4	IRAK4 Deficiency 01/2021 - 12/2006
4	Incontinentia Pigmenti (Bloch Sulzberger Syndrome) 01/2021 - 10/2002
4	autosomal recessive Candidiasis familial chronic mucocutaneous 01/2020 - 12/2012
4	Abscess 01/2017 - 01/2008
4	Hypersensitivity (Allergy) 03/2016 - 12/2005
4	Intellectual Disability (Idiocy) 05/2015 - 06/2010
4	Sepsis (Septicemia) 11/2009 - 04/2004
3	COVID-19 related pediatric multisystem inflammatory disease 03/2022 - 10/2021
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 10/2002
3	Cytokine Release Syndrome 01/2022 - 01/2018
3	Atopic Dermatitis (Atopic Eczema) 01/2021 - 09/2015
3	Reinfection 01/2021 - 01/2018
3	Yellow Fever 01/2021 - 01/2016
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2020 - 11/2013
3	Invasive Fungal Infections 01/2020 - 10/2013
3	Tyrosine Kinase 2 Deficiency 01/2020 - 06/2012
3	Primary Immunodeficiency Diseases 01/2020 - 05/2005
3	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 01/2017 - 03/2009
3	Lymphadenitis (Adenitis) 01/2017 - 08/2007
3	Asthma (Bronchial Asthma) 03/2016 - 12/2005
3	Fever (Fevers) 11/2014 - 01/2008
3	Pneumococcal Infections 11/2010 - 12/2003

Drug/Important Bio-Agent (IBA)

37	AutoantibodiesIBA 10/2022 - 01/2004
28	InterferonsIBA 11/2021 - 08/2005
24	Interferon Type IIBA 10/2022 - 06/2007
23	CytokinesIBA 01/2022 - 12/2004
22	Proteins (Proteins, Gene)FDA Link 03/2022 - 02/2004
22	Interleukin-12 (IL 12)IBA 08/2021 - 02/2002
20	VaccinesIBA 01/2022 - 07/2003
20	Interleukin-17 (Interleukin 17)IBA 11/2021 - 02/2010
15	NF-kappa B (NF-kB)IBA 08/2008 - 06/2002
14	Antiviral Agents (Antivirals)IBA 01/2022 - 12/2007
10	Interferon-gamma (Interferon, gamma)IBA 01/2021 - 01/2004
10	Interleukin-12 Receptors (Interleukin 12 Receptor)IBA 01/2019 - 06/2003
9	Immunoglobulin E (IgE)IBA 11/2018 - 12/2005
8	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2021 - 08/2008
8	InterleukinsIBA 01/2020 - 08/2005
7	Biological ProductsIBA 01/2022 - 01/2008
7	Interleukin-23 (Interleukin 23)IBA 08/2021 - 02/2008
7	Interleukin-12 Subunit p40IBA 06/2021 - 12/2005
7	BCG Vaccine FDA Link 06/2020 - 01/2013
7	Phosphotransferases (Kinase)IBA 01/2019 - 04/2004
7	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2017 - 12/2003
7	Interferon gamma ReceptorIBA 09/2010 - 03/2003
6	AntibodiesIBA 01/2022 - 11/2008
6	Toll-Like Receptor 3IBA 11/2020 - 09/2010
6	Immunoglobulin G (IgG)IBA 10/2020 - 01/2008
6	STAT1 Transcription FactorIBA 01/2020 - 01/2005
6	Anti-Bacterial Agents (Antibiotics)IBA 07/2015 - 02/2002
6	Interferon LambdaIBA 12/2011 - 06/2007
5	AntigensIBA 03/2022 - 04/2004
5	Interleukin-6 (Interleukin 6)IBA 01/2022 - 01/2008
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2005
5	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2015 - 12/2006
5	Complement System Proteins (Complement)IBA 07/2014 - 12/2003
4	Pharmaceutical PreparationsIBA 01/2022 - 09/2010
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 10/2003
4	Tuberculin (PPD)IBA 01/2021 - 11/2009
4	Codon (Codons)IBA 09/2012 - 06/2002
4	NF-KappaB Inhibitor alphaIBA 07/2006 - 10/2003
3	Immunoglobulin M (IgM)IBA 01/2022 - 05/2003
3	RNA (Ribonucleic Acid)IBA 03/2021 - 01/2018
3	Attenuated VaccinesIBA 01/2021 - 01/2019
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 05/2014
3	Interleukin-27 (Interleukin 27)IBA 01/2021 - 06/2009
3	LigandsIBA 01/2018 - 10/2003
3	Interleukin-10 (Interleukin 10)IBA 09/2015 - 03/2009
3	Transcription Factors (Transcription Factor)IBA 04/2015 - 02/2004
3	Interleukin-1 Receptor-Associated KinasesIBA 03/2015 - 04/2004
3	I-kappa B KinaseIBA 07/2006 - 10/2003

Therapy/Procedure

18	Therapeutics 01/2022 - 02/2003
5	Hematopoietic Stem Cell Transplantation 01/2018 - 04/2006
4	Transplantation 01/2018 - 07/2006
3	Critical Care (Surgical Intensive Care) 01/2022 - 11/2021
3	Antibiotic Prophylaxis 07/2012 - 03/2002